Cart
Checkout Secure
hbcprotocols@gmail.com - (800) 497-3742

Got a Question? Call Us

1 (800) 497-3742

Mon-Sat 9am-6pm Pacific Time

Neurobiological effects of Hyperforin and its potential in Alzheimer’s disease therapy

By HBC Protocols February 01, 2012 0 comments

Abstract
St. John’s Wort (SJW) has been used medicinally for over 5,000 years. Relatively recently, one of its phloroglucinol derivatives, hyperforin, has emerged as a compound of interest. Hyperforin first gained attention as the constituent of SJW responsible for its antidepressant effects. Since then, several of its neurobiological effects have been described, including neurotransmitter re-uptake inhibition, the ability to increase intracellular sodium and calcium levels, canonical transient receptor potential 6 (TRPC6) activation, N-methyl-D-aspartic acid (NMDA) receptor antagonism as well as antioxidant and anti-inflammatory properties. Until recently, its pharmacological actions outside of depression had not been investigated. However, hyperforin has been shown to have cognitive enhancing and memory facilitating properties. Importantly, it has been shown to have neuroprotective effects against Alzheimer’s disease (AD) neuropathology, including the ability to disassemble amyloid-beta (Abeta) aggregates in vitro, decrease astrogliosis and microglia activation, as well as improve spatial memory in vivo. This review will examine some of the early studies involving hyperforin and its effects in the central nervous system (CNS), with an emphasis on its potential use in AD therapy. With further investigation, hyperforin could emerge to be a likely therapeutical candidate in the treatment of this disease.

Griffith TN, Varela-Nallar L, Dinamarca MC, Inestrosa NC.

Source
CARE & CRCP, Biomedical, Center, P. Universidad Católica de Chile, P.O. Box 114-D, Santiago, Chile.

PMID:

20015041

[PubMed – indexed for MEDLINE]

Older Post Newer Post

Newsletter

Here's What Our Customers Think:

Added to cart!
Effinex™ Idebenone with Vitamin C 300mg
Someone purchased a 6 minutes ago from Berlin, Germany
HYPERICUM PERFORATUM II
Someone purchased a 6 minutes ago from Berlin, Germany
Idebenone 200mg - 50 Capsules
Someone purchased a 6 minutes ago from Berlin, Germany
Idebenone 500mg 60 Capsules
Someone purchased a 6 minutes ago from Berlin, Germany
Idebenone 50mg - 180 Count Bottle
Someone purchased a 6 minutes ago from Berlin, Germany
L-Tryptophan - 180 Capsules
Someone purchased a 6 minutes ago from Berlin, Germany
Multi-Life Vitamins w/ Digestive Enzymes
Someone purchased a 6 minutes ago from Berlin, Germany
Omega Complex DHA / EPA - 270 Soft Gels
Someone purchased a 6 minutes ago from Berlin, Germany
Sceletium Tortuosum
Someone purchased a 6 minutes ago from Berlin, Germany
SJW HOMEOPATHIC SPRAY
Someone purchased a 6 minutes ago from Berlin, Germany
St. Johns Wort Supplement
Someone purchased a 6 minutes ago from Berlin, Germany
sleepwelldreambetter@gmail.com Free shipping when you order over XX You Have Qualified for Free Shipping Spend $x to Unlock Free Shipping You Have Achieved Free Shipping Free Shipping For Over $x to hbcprotocols@gmail.com - (800) 497-3742 You Have Achieved Free Shipping Free shipping when you order over XX ou Have Qualified for Free Shipping