Cart
Checkout Secure
hbcprotocols@gmail.com - (800) 497-3742

Got a Question? Call Us

1 (800) 497-3742

Mon-Sat 9am-6pm Pacific Time

Yale University study may have identified a depression gene

By HBC Protocols October 17, 2010 0 comments

Researchers at Yale University say they have identified a gene as a possible cause for depression. The discovery could yield a new version of antidepressants that could target the specific gene known as MKP-1.The study conducted genome scans on tissue samples from 21 dead people who had depression and compared those to tissues samples from healthy people. The MKP-1 gene was more than twice as strong in those who had depression. The researchers then transferred the genes to mice and found the mice displayed depressive behavior associated with too much stress.

According to the study, the MKP-1 gene shuts down a pathway in the brain that causes neurons to not function properly. Previous studies had shown a similar breakdown of the pathways.

Researchers hope the findings can lead to a new class of drugs that can target the gene rather than targeting the chemicals in the brain including serotonin, norepinephrine, and dopamine. It could revolutionize depression medications which have typically relied on selective serotonin reuptake inhibitors.

Negative regulation through dephosphorylation

MKP-1 (Map Kinase Phosphatase -1)

Serum activates signal transduction to nucleus where expression of several genes are activated. One of those genes is MKP-1, whose gene products appear about 20 minutes after the addition of serum. MKP-1 is stabilized by the ERK kinase which is also the substrate for dephosphorylation by MKP-1.


Older Post Newer Post

Newsletter

Here's What Our Customers Think:

Added to cart!
Effinex™ Idebenone with Vitamin C 300mg
Someone purchased a 12 minutes ago from Berlin, Germany
HYPERICUM PERFORATUM II
Someone purchased a 12 minutes ago from Berlin, Germany
Idebenone 200mg - 50 Capsules
Someone purchased a 12 minutes ago from Berlin, Germany
Idebenone 500mg 60 Capsules
Someone purchased a 12 minutes ago from Berlin, Germany
Idebenone 50mg - 180 Count Bottle
Someone purchased a 12 minutes ago from Berlin, Germany
L-Tryptophan - 180 Capsules
Someone purchased a 12 minutes ago from Berlin, Germany
Multi-Life Vitamins w/ Digestive Enzymes
Someone purchased a 12 minutes ago from Berlin, Germany
Omega Complex DHA / EPA - 270 Soft Gels
Someone purchased a 12 minutes ago from Berlin, Germany
Sceletium Tortuosum
Someone purchased a 12 minutes ago from Berlin, Germany
SJW HOMEOPATHIC SPRAY
Someone purchased a 12 minutes ago from Berlin, Germany
St. Johns Wort Supplement
Someone purchased a 12 minutes ago from Berlin, Germany
sleepwelldreambetter@gmail.com Free shipping when you order over XX You Have Qualified for Free Shipping Spend $x to Unlock Free Shipping You Have Achieved Free Shipping Free Shipping For Over $x to hbcprotocols@gmail.com - (800) 497-3742 You Have Achieved Free Shipping Free shipping when you order over XX ou Have Qualified for Free Shipping