Depression isn’t simple. When we are truly depressed our friends usually can’t reach us—because we don’t want friends around. And the phone, texts, and door goes unanswered. Basically, such people are becoming their own worst enemy and are more attracted to self-persecution rather than comfort. Finding your way out of the unique prison of your own depression must begin with accepting and valuing yourself.
We know this is much more easily said than done which is why we offer so many alternatives to support your way out of the bell jar (Sylvia Plath described her depression as being trapped under a bell jar) or that dark alleyway that seems to stretch into infinity, but here is a fundamental idea for a way out.
Accept and value yourself. Accepting yourself means no longer having to live in the past, feeling guilty about your wickedness, or in the future, fearing what is to come. Instead, you can live in the present and be, if not happy, than not unhappy, in the here and now. Treat yourself as your own best friend. Never think of yourself as not good enough. Never say anything against yourself that can potentially bring you down. As you become your own best friend by doing for yourself what you always wanted in a best friend, the universe will start to answer you in like and kind.
Washington: A new study reviewed in the Cochrane Library finds that depressed smokers are more likely to successfully quit than their non-depressed counterparts. Moreover, they stop smoking longer and benefit overall from mood management interventions after they quit smoking. The lead researcher Regina van der Meer, at the Dutch Expert Centre on Tobacco Control studied 49 randomized controlled trials, including 33 trials that focused on smoking cessation. The way we look at it, it is all about anticipation. By not smoking and exercising discipline smokers are able to release more dopamine than if they were to smoke. Dopamine is the anticipation neurotransmitter. Nicotine triggers dopamine release. This is why cigarettes are so addictive. Cocaine also triggers dopamine release. Gambling releases dopamine release. Now you can raise your dopamine naturally and quit smoking with ,NeuroPlex: a dopamine, oxytocin, brain endorphin sublingual formulation.
London: Cameron Diaz admits she accepted the offer to appear in movie `Knight and Day` to battle the grief of her father`s death.
The 37-year-old actress is paired opposite Hollywood hunk Tom Cruise in the James Mangold`s directorial venture. Diaz was devastated when her father Emilio died of pneumonia in April 2008 during the filming of `My Sister`s Keeper`. She admits that she took the role opposite Cruise because she was desperate to have some “fun” afterwards, Contact music reported.
Nicon, 22, committed suicide after he fell 20ft to his death from his apartment in Italy. He is thought to have been depressed after breaking up with his girlfriend.
The model, who was the male “face” of the British fashion label Burberry, died at the start of the Milan Men’s fashion week. Tom also worked for Louis Vuitton, Hugo Boss and Versace, for whom he had attended a show rehearsal the day he died. Fashion Week will go ahead with a tribute to the Frenchman.
Scientists have for the first time obtained evidence for the link between cholesterol-lowering drugs and depression in people taking these drugs to prevent heart attack.
They have found that cholesterol-lowering drug may affect the activity of a brain chemical that controls mood and behavior and thereby trigger anxiety and depression.
Cholesterol, a wax like substance, is the main culprit in heart disease. Although the body needs it, a high level of serum cholesterol causes blockage of coronary arteries thereby reducing blood circulation to the heart muscles leading to heart attack. A class of drugs called ‘statins’ which lower the cholesterol level — by inhibiting a key enzyme responsible for its biosynthesis in the body – are the highest selling drugs in the global market and in clinical history with an estimated sale of 25 billion USD annually. They are extensively used as oral drugs to treat “hypercholesterolemia.” Although they are very effective in reducing cholesterol levels in humans, there is a growing concern that chronic use of statins causes depression and anxiety in patients. “In the last few years, a number of publications in medical journals have reported apparent symptoms of anxiety and major depression in patients upon long-term statin administration,” says Amitabha Chattopadhyay at the Centre for Cellular and Molecular Biology in Hyderabad.
Why should change in the level of a small greasy molecule in the body lead to changes in complex behavioral manifestations such as mood and anxiety has been a puzzle and there has been no molecular evidence to explain this till date. But a paper by Chattopadhyay’s group just published in the journal Biochemistry sheds novel insight into the link between use of statins and mood disorders.
The scientists have shown that chronic cholesterol depletion by statins impairs the function of the receptors for serotonin, a neurotransmitter in the brain that controls mood and behavior. Chattopadhyay’s group has previously shown that maintaining normal cholesterol levels is important for the function of cell membrane receptors for serotonin. Their latest study showed that cholesterol depletion in the brain affects the function of serotonin receptors leading to depression and anxiety.
The scientists demonstrated this in a test-tube experiment by studying the effect of statin on human serotonin receptors expressed in animal cells called “Chinese Hamster Ovary” cells. Their results showed that long-term treatment with the drug caused significant changes in the structure and function of serotonin receptors. Adding cholesterol to cells treated with statin restored the function of the receptor to normal level.
These novel results represent the first report describing the effect of long-term cholesterol depletion on this type of neurotransmitter receptor and suggest that chronic, low cholesterol levels in the brain may trigger anxiety and depression.